The protocol for the review titled ‘The effect of ANKK1 Taq1A and DRD2 C957T polymorphisms on executive function: a systematic review and meta-analysis’ was developed with the support of the LIH Systematic Review Program. Kristel, Kevin and Kyla all attended the LIH 3 day workshop program during the spring in 2016, and now three short years later it is available online in Neuroscience & Biobehavioral Reviews: https://www.sciencedirect.com/science/article/pii/S0149763418308649?via%3Dihub
This review presented us with many challenges along the way, with much heterogeneity and risk of bias discrepancies for third reviewer discussions! Well done to the team: Kristel Klaus, Kevin Butler, Ffion Curtis, Chris Bridle, and Kyla Pennington!
•The associations of ANKK1 Taq1A and DRD2 C957 T with executive function (EF) were explored.
•The genetic associations with EF were systematically investigated in healthy adults.
•Separate meta-analyses were carried out for each polymorphism and EF domain.
•The results suggested a limited effect of these polymorphisms on EF.
•Results suggested high variability in the EF tests and study populations.